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The association of NEDD1/GCP-WD with -TuRC is required for the centrosomal recruitment of -TuRC and microtubule nucleation in many mammalian cell lines (Fig

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To achieve this, a thorough understanding of the impact of a specific patients CKD is essential, so that a care plan can be developed targeting the key issues that are likely to be affecting quality of life and longevity while taking into account the carers ability to deliver the treatments, as well as cost consideration of the treatment and monitoring that is required